P3.01-038 STAT3 and Src-YAP1 Inhibition Results in Greater Necitumumab Sensitivity in Lung Squamous Cell Carcinoma

Squamous cell carcinoma of lung with unusual site of metastasis

Background: Lung cancer ranks among the most common and most lethal malignancies worldwide. Once vascular or lymphatic invasions occur, metastatic dissemination to distant sites is common. Bone, liver, adrenals, and brain are the most frequent sites of the distant disease. In this study we present a case of squamous cell carcinoma of lung with metastasis of the left knee bursa.Case presentation...

Clinical potential of necitumumab in non-small cell lung carcinoma

Despite significant progress, new therapeutic approaches for advanced non-small cell lung cancer (NSCLC) are highly needed, particularly for the treatment of patients with squamous cell carcinoma. The epidermal growth factor receptor (EGFR) is often overexpressed in NSCLC and represents a relevant target for specific treatments. Although EGFR mutations are more frequent in non-squamous histolog...

Necitumumab: a new therapeutic option for squamous cell lung cancer?

Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma

The intracytoplasmic tyrosine kinase Src serves both as a conduit and a regulator for multiple processes required for the proliferation and survival cancer cells. In some cancers, Src engages with receptor tyrosine kinases to mediate downstream signaling and in other cancers, it regulates gene expression. Src therefore represents a viable oncologic target. However, clinical responses to Src inh...

The Usefulness of CD10 in Distinguishing between Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma

Background & Objectives:  CD10 is a cell surface enzyme with metalloendopeptidase activity, also known as Common Acute Lymphoblastic Leukaemia Antigen, which mainly serves as a marker for acute lymphoblastic leukemia (ALL). To date and to the best of our knowledge, only few comparative immunohistochemical studies have assessed CD10 expression in cutaneous epithelial neoplasms. Our goal was to d...